Semaglutide is an exciting new medication that is transforming weight loss treatment. As the leading hormone clinic in Highland, the Harmonize Hormones specializes in cutting-edge solutions like Semaglutide to help patients achieve sustainable fat loss and better health.
Semaglutide is a synthetic hormone belonging to the GLP-1 receptor agonist class of compounds. It mimics the effects of the naturally occurring GLP-1 hormone produced in the gastrointestinal tract and acts to stimulate insulin production while suppressing appetite.
Initially developed as a treatment for type 2 diabetes, Semaglutide soon showed remarkable potential as a weight loss aid. In 2021, the 1mg dose of Semaglutide specifically for obesity treatment was approved by the FDA under the brand name Wegovy.
Key benefits of Semaglutide weight loss treatment:
In clinical trials lasting up to 20 months, over 2⁄3 of patients treated with Semaglutide lost over 10% of their initial weight. No other anti-obesity medication has demonstrated such stellar and sustained results.
There are two primary ways that Semaglutide exerts its weight loss effects:
Additionally, Semaglutide may have a role in:
The combined impact of these effects enables substantial fat burning paired with reduced hunger, allowing easier adoption of a calorie deficit without struggles or starvation sensations.
Semaglutide has been extensively studied in individuals with obesity, defined as having a BMI of 30 kg/m2 or higher. It has proven both safe and effective for most patients meeting this criterion.
Some key factors that make someone a good fit for Semaglutide obesity treatment:
Semaglutide promotes weight loss regardless of baseline glucose tolerance or diabetes status. However, it provides added management of blood sugar for patients with obesity and diabetes.
Those with milder overweight (BMI 25-30 kg/m2) can also potentially benefit but should first attempt intensive lifestyle modification focused on nutrition and exercise.
Semaglutide was designed for weekly injection to promote compliance compared to daily or twice-daily doses required for other GLP-1 drugs. Treatment starts with a 4-week ramp-up phase:
This allows the body to adjust to Semaglutide and minimizes initial gastrointestinal side effects. These typically resolve within days to weeks of continued use.
Semaglutide comes in a pre-filled pen for self-injection into the thigh, stomach area, or upper arm. The needle length is just 5mm for comfort. Injection takes only 10-15 seconds once weekly, greatly enhancing adherence.
We recommend administration on the same weekday at roughly the same time for optimal consistency and benefits. While not yet FDA approved, clinical trials are also evaluating a 2.4mg maintenance dose for additional weight loss efficacy.
In large-scale phase 3 trials, Semaglutide users experienced the following after 68 weeks of treatment on average:
Those with prediabetes or T2D also saw a 0.2-0.4% improvement in HbA1c and a 19 mg/dL median reduction in triglycerides.
Benefits started early and peaked around 40 weeks before plateauing. However, continued calorie deficit enabled weight maintenance long-term. Following discontinuation, participants gradually regained about 50-60% of lost weight over 72 weeks - similar to results after intensive lifestyle interventions.
This means with sustained healthy nutrition and activity habits encouraged through our lifestyle coaching, most patients can keep the majority of weight off. Some may intermittently cycle back on Semaglutide as needed for added support.
As an injectable product bypassing initial breakdown, Semaglutide poses a relatively low risk of systemic side effects. It was very well tolerated by most subjects in clinical testing.
However, being a GLP-1 agonist, mild gastrointestinal disturbance is common early in treatment. This manifests as transient nausea, vomiting, diarrhea, or constipation lasting under a week. Staying well hydrated aids recovery.
Rarely, Semaglutide can cause:
Contraindications where Semaglutide should not be prescribed:
We monitor patients very closely and will order bloodwork, gallbladder ultrasounds, or other testing if any concerning or high-risk symptoms manifest. So far, Semaglutide appears very promising from a safety standpoint for suitable patients actively working towards lifestyle improvement.
Obesity is a chronic disorder that often follows a relapsing-remitting course like other hormonal conditions. Losing weight through calorie restriction alone triggers homeostatic mechanisms aiming to return individuals to their original elevated weight.
This means that lifestyle intervention alone has modest long-term success in maintaining substantial fat loss. Up to 80% of lost weight is gradually regained because hunger hormones and metabolism conspire to thwart sustained progress.
Medications like Semaglutide finally offer lasting aid by acting at a hormonal level to facilitate behavior change. In essence, they "trick" the endocrine system into feeling comfort at a lower new setpoint so that improved eating and activity patterns can successfully continue.
At the Harmonize Hormones, we provide comprehensive care - pharmacologic weight loss therapies aligned with evidence-based coaching for nutrition, physical activity, sleep, and stress management tailored to each patient's needs and preferences. This multi-modal approach offers the best chance at losing significant weight and keeping it off compared to single interventions alone.
We also closely track objective metrics at each visit - measurements, percent body fat, and lab markers of metabolic health. This allows promptly catching any deficiencies indicating needs for medication adjustments or ancillary treatments.
With over 15 years specializing in hormonal therapies for various conditions, our physicians have the knowledge to properly administer drugs like Semaglutide and mitigate side effects. We combine art and science to develop personalized plans resulting in the most impressive transformations possible. Everything is carefully calibrated for efficient results while always prioritizing safety.
Despite revolutionary data demonstrating Semaglutide's superiority for durable weight loss, some stubborn myths and misconceptions continue circulating online and in the community. As leaders in obesity pharmacotherapy, we feel addressing these fallacies is important:
Myth: Semaglutide is just another fad diet drug hyped to exploit obesity rather than meaningfully solve it long-term.
Fact: Unlike past weight loss meds, Semaglutide does not act by suppressing either absorption of nutrients or through stimulating metabolism alone. Instead, it leverages prudent targeting of an endogenous gut pathway regulating hunger, satiety, and glucose control.
Activating GLP-1 receptors yields better interactions affecting far more pathways contributing to adiposity than previous simplistic attempts enhancing willpower alone. And unlike amphetamines or thyroid hormones, stimulation levels with Semaglutide parallel natural physiology.
Efficacy and safety data from numerous late-phase trials indicate exceptional performance for responder subgroups. Although not magic, appropriate patients using Semaglutide within a holistic program tend to achieve substantial loss well within normal parameters that remains fairly stable years later following cessation.
This suggests resetting of the "set point" is possible, not just transient amplified lipolysis subject to compensation rebounding weight afterward. Progressive science building on previous missteps rarely follows ready scripts. But prudent skepticism must also acknowledge convincing evidence where due.
Myth: A medication or injection could never "cure" obesity without fixing bad habits - it is merely a crutch allowing avoidance of taking personal responsibility.
Fact: Obesity has complex underpinnings, involving not just behavioral but genetic, epigenetic, hormonal, and environmental contributors too. As with most diseases, it does not stem from moral failings about "personal responsibility."
Rather, feedback loops spanning myriad domains conspire against sustainable change. Circulating signals from adipocytes, gastric tissues, and even the microbiome overwhelm cognitive restraint attempting adherence against relentless hunger.
Like insulin for diabetes or levothyroxine for hypothyroidism, obesity itself is a chronic condition with excellent grounds for properly calibrated pharmaceutical augmentation targeting regulatory signaling deficits.
When combined appropriately with lifestyle therapy, medications like Semaglutide act akin to crutches - not allowing avoidance but beneficially supporting and enabling mobility where it remains seriously impaired otherwise.
Myth: Receiving an expensive prescription injection weekly trains patients to passively expect solutions from external products rather than looking inward.
Fact: Injection pens take seconds to administer oneself weekly. This route bypasses much first-pass metabolism for maximal availability without a daily burden. And unlike OTC supplements, precise API dosing prevents under or overconsumption.
Overall, Semaglutide demands far more patient discipline through self-care, planning, and adherence than popping a daily pill. Responsibly managing the treatment course builds self-efficacy and confidence via biofeedback towards better habits over time.
Gradual assumption of increasing autonomy improves the likelihood of sustained success once independent of medication, unlike abrupt termination where internal capability remains inadequate, limiting generalizability without such scaffolding prematurely removed rather than faded.
Since hypothalamic dysfunction contributes strongly to obesity pathology via dysregulation of hormones managing hunger/satiety setpoints, properly assessing these signaling chemicals and peptide factors is prudent for tailored interventions.
Common serum tests useful for gauging patient needs include:
Tracking patient levels for the above hormones before/during/after treatment demonstrates relative deficiencies indicating needs for medication adjustment like altered Semaglutide dosing or supplemental agents.
We help interpret lab findings and provide specific recommendations for optimizing aberrant metrics. Follow-up testing also confirms improvement towards normal ranges as patients progress towards health goals.
For ideal patient care, we advise choosing an experienced physician board certified in obesity medicine comfortable providing such pharmacotherapy while attending to possible contraindications. An established specialty clinic focused on weight loss enables proper oversight for efficacy and safety.
While regular weekly Semaglutide administration aids significant weight loss for most patients already, an array of emerging strategies appear capable of further optimizing potency:
As innovators in the weight loss space, Harmonize Hormones actively monitors emerging research to offer patients access to the most progressive treatment options. We avoid one-size-fits-all protocols, always personalizing care for a superior benefit-risk ratio tailored to each individual's needs.
While weekly subcutaneous injection is the standard route of administration, various alternative Semaglutide formulations offer different advantages:
| Method | Frequency | Pain | Absorption | Cost | Special Considerations |
|---|---|---|---|---|---|
| Subcutaneous injection | Once weekly | Little pain with small needle | Consistent absorption with minimal peaks/troughs | $$$$ | Prefilled disposable pen offers convenience for self-administration |
| Custom oral capsules | Daily | None | Slower less reliable extent absorption with gastric breakdown | $$$ | Compounding single doses limits precision. Must avoid food before/after for 20 minutes without liquids to maximize bioavailability |
| Intranasal | Twice daily | Temporary nasal irritation possible | Partial variable biodistribution to brain, rapid peaks then fast clearance | $$ | Lower doses suffice leveraging direct nose-to-brain pathway bypassing bloodstream. Less GI side effects but possible nose bleeds. |
| Extended release implants | Once every 1-2 years | Temporary discomfort getting inserted/removed | Steady diffusion from polymer device implanted subdermally/subcutaneously | $$$$ | Eliminates frequent dosing issues but requires minor surgical procedure. Removal similarly needed later. |
| Oral semaglutide (future) |
